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This study investigates the role of high TWAS-active endothelial cells in pulmonary arterial hypertension (PAH) using a combination of transcriptome-wide association studies (TWAS) and single-cell RNA sequencing (scRNA-seq). It identifies three key genes—KLF2, RASIP1, and DEPP1—as significant predictors of endothelial dysfunction in PAH, demonstrating their potential as biomarkers for disease progression. The findings highlight the importance of endothelial cell heterogeneity and provide a framework for und

Author
un9tweelpq
Language
EN

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