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Can I read Cellular Kinetics of an Allergic-type Response in a Sheep Mammary Gland Model of Inflammation on EtoBox?
Cellular Kinetics of an Allergic-type Response in a Sheep Mammary Gland Model of Inflammation by R. J Bischof; E. N. T Meeusen is a Medicine article available to read on EtoBox.
What is Cellular Kinetics of an Allergic-type Response in a Sheep Mammary Gland Model of Inflammation about?
## Summary **Background** Tissue recruitment of eosinophils and activated lymphocytes is a characteristic feature of allergic reactions. However, little is known about the involvement of specific adhesion molecules in the traffic of leucocytes during the allergic response. **Objective** To use a sheep mammary infusion model to characterize the kinetics of cell recruitment and expression of cellular adhesion molecules and activation markers on eosinophils and lymphocytes involved in an allergic‐type response. **Methods** Mature non‐lactating ewes were primed and challenged by direct infusion of the mammary glands with nematode larvae. Using a non‐invasive method of saline infusion and ‘milking’ of the glands, large numbers of inflammatory cells were repeatedly sampled over 10 to 96 h following their migration into the mammary gland lumen, and analyzed by 2‐colour flow cytometry. **Results** Leucocyte recruitment into the mammary lumen was characterized by two separate phases involving an acute neutrophilic response at 10 h post‐challenge, followed by a dramatic reduction in neutrophils and appearance of eosinophils and activated lymphocytes. From 48 h post‐challenge, eosinophils
Who reads Cellular Kinetics of an Allergic-type Response in a Sheep Mammary Gland Model of Inflammation?
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- Author
- R. J Bischof; E. N. T Meeusen
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0954-7894)
- Published
- 2002
- Language
- EN
- Field
- Medicine (Health Sciences)