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Antitumor Monoclonal Antibodies for Radioimmunodetection of Tumors and Drug Targeting by Robert W. Baldwin; Malcolm V. Pimm is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Antitumor Monoclonal Antibodies for Radioimmunodetection of Tumors and Drug Targeting about?

Developments in hybridoma technology leading to the production of monoclonal antibodies recognizing tumor-associated antigens are providing new approaches for the radioimmunodetection of, and drug targeting to, metastases. These developments are illustrated in a series of studies on the in vivo localization of an antihuman-osteogenic sarcoma monoclonal antibody (791T/36) in human tumor xenografts maintained in immunodeprived mice. 131I-labelled 791T/36 antibody localized specifically in osteogenic sarcomas but not in xenografts of other tumors, such as bladder carcinoma T24, which do not express the antigen identified by this antibody. Developing from these studies, various parameters influencing antibody localization in tumors were examined including the kinetics of antibody uptake, the relationshiop between tumor size and antibody binding, and the site of antibody deposition. This provides a basis for considering the potential of antitumor monoclonal antibodies for targeting antitumor agents. Of particular importance here is the observation that antibody is principally located at the periphery of tumors since this will influence the population of cells within a tumor which can be

Who reads Antitumor Monoclonal Antibodies for Radioimmunodetection of Tumors and Drug Targeting?

Author

Robert W. Baldwin; Malcolm V. Pimm

Publisher

Springer; Springer-Verlag; Kluwer Academic Publishers; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0167-7659)

Published

1982

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)