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A Nano-delivery System Based on Preventing Degradation and Promoting Absorption to Improve the Oral Bioavailability of Insulin by Jie Zhou; Jin Zhang; Yiwen Sun; Fusui Luo; Min Guan; Huili Ma; Xiaomeng Dong; Junfen Feng is a Materials Science article available to read on EtoBox.
What is A Nano-delivery System Based on Preventing Degradation and Promoting Absorption to Improve the Oral Bioavailability of Insulin about?
Oral insulin delivery can improve patient compliance and simulate the portal-peripheral insulin concentration gradient produced by endogenous insulin, so oral insulin delivery has a broad prospect. However, some characteristics of the gastrointestinal tract, lead to low oral bioavailability. Therefore, a “ternary mutual-assist” nano-delivery system based on poly(lactide-co-glycolide) (PLGA) as the backbone combined with ionic liquids (IL) and vitamin B12-chitosan (VB12-CS) was constructed in this study, the protein protection performance of IL improves the room temperature stability of the loaded insulin during nanocarrier preparation, transportation and storage to a certain extent, and the protein protection function of IL combined with the slow degradation property of PLGA and the pH-responsive function of VB12-CS to prevent the degradation of insulin in the gastrointestinal tract. In addition, the mucosal adhesion function of VB12-CS, VB12 receptor- and clathrin-mediated transcellular transport involving VB12-CS and IL, and paracellular transport mediated by IL and CS can be combined to improve the intestinal epithelial transport efficiency of insulin, thus, the nanocarrier has
Who reads A Nano-delivery System Based on Preventing Degradation and Promoting Absorption to Improve the Oral Bioavailability of Insulin?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- Jie Zhou; Jin Zhang; Yiwen Sun; Fusui Luo; Min Guan; Huili Ma; Xiaomeng Dong; Junfen Feng
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Materials Science (Physical Sciences)