Opening book details…
Can I read Risk of endometrial cancer for women diagnosed with HNPCC-related colorectal carcinoma on EtoBox?
Risk of endometrial cancer for women diagnosed with HNPCC-related colorectal carcinoma by Andreas Obermair; Danny R. Youlden; Joanne P. Young; Noralane M. Lindor; John A. Baron; Polly Newcomb; Susan Parry; John L. Hopper; Robert Haile; Mark A. Jenkins is a Medicine article available to read on EtoBox.
What is Risk of endometrial cancer for women diagnosed with HNPCC-related colorectal carcinoma about?
## Abstract The risk of endometrial cancer (EC) subsequent to a diagnosis of colorectal cancer in women with a germline mutation in a mismatch repair gene [Lynch syndrome or hereditary non‐polyposis colon cancer (HNPCC)] is unknown. We estimated the risk of EC following a diagnosis of colorectal carcinoma (CRC) for women with Lynch syndrome. A retrospective cohort study was performed on women diagnosed with CRC with a germline mutation in a mismatch repair (MMR) gene (Lynch syndrome cases), and women with microsatellite stable (MSS) CRC who were not known to carry a germline mutation (non‐Lynch cases), identified from the Colon Cancer Family Registry. The incidence of EC following CRC was estimated and compared for women with and without Lynch syndrome, using adjusted hazards ratios calculated for time at risk among each group. A total of 112 women with Lynch syndrome and a previous diagnosis of CRC were compared with 908 women without Lynch and with a MSS CRC diagnosis. The estimated 10‐year cumulative risk of EC subsequent to CRC was 23.4% [95% confidence interval (CI): 15–36%] for Lynch syndrome women compared with 1.6% (95% CI: 0.7–3.8%) for non‐Lynch women. After adjusting for
Who reads Risk of endometrial cancer for women diagnosed with HNPCC-related colorectal carcinoma?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Andreas Obermair; Danny R. Youlden; Joanne P. Young; Noralane M. Lindor; John A. Baron; Polly Newcomb; Susan Parry; John L. Hopper; Robert Haile; Mark A. Jenkins
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)