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Increased osteoblast and decreased Staphylococcus epidermidis functions on nanophase ZnO and TiO~2~ by Gabriel Colon; Brian C. Ward; Thomas J. Webster is a Engineering article available to read on EtoBox.

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## Abstract Many engineers and surgeons trace implant failure to poor osseointegration (or the bonding of an orthopedic implant to juxtaposed bone) and/or bacteria infection. By using novel nanotopographies, researchers have shown that nanostructured ceramics, carbon fibers, polymers, metals, and composites enhance osteoblast adhesion and calcium/phosphate mineral deposition. However, the function of bacteria on materials with nanostructured surfaces remains largely uninvestigated. This is despite the fact that during normal surgical insertion of an orthopedic implant, bacteria from the patient's own skin and/or mucosa enters the wound site. These bacteria (namely, __Staphylococcus epidermidis__) irreversibly adhere to an implant surface while various physiological stresses induce alterations in the bacterial growth rate leading to biofilm formation. Because of their integral role in determining the success of orthopedic implants, the objective of this __in vitro__ study was to examine the functions of (i) __S. epidermidis__ and (ii) osteoblasts (or bone‐forming cells) on ZnO and titania (TiO~2~), which possess nanostructured compared to microstructured surface features. ZnO is a w

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Author

Gabriel Colon; Brian C. Ward; Thomas J. Webster

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1549-3296)

Published

2006

Language

EN

Field

Engineering (Physical Sciences)