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Can I read Inhibition of Alveolar Bone Loss by Matrix Metalloproteinase Inhibitors in Exjreimental Jreiodontal Disease on EtoBox?
Inhibition of Alveolar Bone Loss by Matrix Metalloproteinase Inhibitors in Exjreimental Jreiodontal Disease by Nungavaram S. Ramamurthy; Jing-wen Xu; John Bird; Andrew Baxter; Ranjev Bhogal; Ruth Wills; Bob Watson; David Owen; Mark Wolff; Robert A. Greenwald is a Dentistry article available to read on EtoBox.
What is Inhibition of Alveolar Bone Loss by Matrix Metalloproteinase Inhibitors in Exjreimental Jreiodontal Disease about?
Jreiodontal disease is characterized by excessive host collagenase resulting in loss of gingival and jreiodontal ligament collagen and adjacent alveolar bone. Intragingival endotoxin injection induces a model of jreiodontal disease characterized by rapid bone loss with biochemical features similar to that of naturally occurring adult jreiodontitis. CH1766, a peptide with a zinc binding moeity which fits into the active site of the enzyme, and CH6631, a hydroxamic acid derivative with aryl‐substituted sulphonamide residues, are inhibitors of matrix metalloproteinases (MMPIs) with differing inhibitory profiles as characterized by __in vitro__ assays. In this study, endotoxin was injected into the gingivae of rats which were then treated orally with either 3 mg/kg or 30 mg/kg of one of the two inhibitory compounds. The gingival tissues were assessed for collagenase and gelatinase activity, plus three different pro‐inflammatory cytokines. In addition, alveolar bone height in defleshed jaws was studied by computerized morphometric analysis and scanning electron microscopy. Both drugs reduced active and/or total MMP activity, in many cases to normal, and also partially normalized cytokin
Who reads Inhibition of Alveolar Bone Loss by Matrix Metalloproteinase Inhibitors in Exjreimental Jreiodontal Disease?
It is typically read by researchers, students, and practitioners in Dentistry.
- Author
- Nungavaram S. Ramamurthy; Jing-wen Xu; John Bird; Andrew Baxter; Ranjev Bhogal; Ruth Wills; Bob Watson; David Owen; Mark Wolff; Robert A. Greenwald
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0022-3484)
- Published
- 2002
- Language
- EN
- Field
- Dentistry (Health Sciences)