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Trial of Selective Early Treatment of Patent Ductus Arteriosus with Ibuprofen by Samir Gupta; Nimish V. Subhedar; Jennifer L. Bell; David Field; Ursula Bowler; Elizabeth Hutchison; Sam Johnson; Wilf Kelsall; Justine Pepperell; Tracy Roberts; Sunil Sinha; Kayleigh Stanbury; Jonathan Wyllie; Pollyanna Hardy; Edmund Juszczak is a Medicine article available to read on EtoBox.

What is Trial of Selective Early Treatment of Patent Ductus Arteriosus with Ibuprofen about?

## Background The cyclooxygenase inhibitor ibuprofen may be used to treat a patent ductus arteriosus (PDA) in preterm infants. We hypothesized that selective early treatment of large PDAs with ibuprofen would improve short-term outcomes. ## Methods In this multicenter, randomized, double-blind, placebo-controlled trial evaluating early (up to 72 hours) treatment with ibuprofen for a large PDA (diameter □ 1.5 mm and pulsatile flow) in extreme preterm infants (born between 23 weeks+0 days and 28 weeks+6 days’ gestation), we randomly assigned 326 infants to receive ibuprofen and 327 to receive placebo. The primary outcome was a composite of death or moderate or severe bronchopulmonary dysplasia (BPD) at 36 weeks post-menstrual age. ## Results The primary outcome occurred in 220 of 318 infants (69.2%) assigned to ibuprofen and 202 of 318 infants (63.5%) assigned to placebo (adjusted risk ratio [aRR], 1.09; 95% confidence interval (CI), 0.98 to 1.20; p=0.10). Death occurred in 44 of 323 infants (13.6%) assigned to ibuprofen and 33 of 321 infants (10.3%) assigned to placebo (aRR, 1.32; 95% CI, 0.92 to 1.90). Among infants that survived to 36 weeks’ post-menstrual age, moderate or severe

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Author

Samir Gupta; Nimish V. Subhedar; Jennifer L. Bell; David Field; Ursula Bowler; Elizabeth Hutchison; Sam Johnson; Wilf Kelsall; Justine Pepperell; Tracy Roberts; Sunil Sinha; Kayleigh Stanbury; Jonathan Wyllie; Pollyanna Hardy; Edmund Juszczak

Publisher

Massachusetts Medical Society

Published

2024

Language

EN

Field

Medicine (Health Sciences)