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Impact of geometrical uncertainties on 3D CRT and IMRT dose distributions for lung cancer treatment by Marco Schwarz; Joris Van der Geer; Marcel Van Herk; Joos V. Lebesque; Ben J. Mijnheer; Eugène M.F. Damen is a Medicine article available to read on EtoBox.
What is Impact of geometrical uncertainties on 3D CRT and IMRT dose distributions for lung cancer treatment about?
## Purpose: To quantify the effect of set-up errors and respiratory motion on dose distributions for non-small cell lung cancer (nsclc) treatment. ## Methods and materials: Irradiations of 5 nsclc patients were planned with 3 techniques, two (conformal radiation therapy (crt) and intensity modulated radiation therapy (imrt1)) with a homogeneous dose in the planning target volume (ptv) and a third (imrt2) with dose heterogeneity. set-up errors were simulated for gross target volume (gtv) and organs at risk (oars). for the gtv, the respiration was also simulated with a periodical motion around a varying average. two configurations were studied for the breathing motion, to describe the situations of free-breathing (fb) and respiration-correlated (rc) ct scans, each with 2 amplitudes (5 and 10 mm), thus resulting in 4 scenarios (fb\_5, fb\_10, rc\_5 and rc\_10). five thousand treatment courses were simulated, producing probability distributions for the dosimetric parameters. ## Results: For crt and imrt1, rc\_5, rc\_10 and fb\_5 were associated with a small degradation of the gtv coverage. imrt2 with fb\_10 showed the largest deterioration of the gtv dosimetric indices, reaching 7% for
Who reads Impact of geometrical uncertainties on 3D CRT and IMRT dose distributions for lung cancer treatment?
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- Author
- Marco Schwarz; Joris Van der Geer; Marcel Van Herk; Joos V. Lebesque; Ben J. Mijnheer; Eugène M.F. Damen
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)
- Published
- 2006
- Language
- EN
- Field
- Medicine (Health Sciences)