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Inhibition of Caffeine Metabolism by 5-Methoxypsoralen in Patients with Psoriasis by E. K. BENDRISS; Y. BECHTEL; A. BENDRISS; Ph. HUMBERT; G. PAINTAUD; J. MAGNETTE; P. AGACHE; P. R. BECHTEL is a Medicine article available to read on EtoBox.
What is Inhibition of Caffeine Metabolism by 5-Methoxypsoralen in Patients with Psoriasis about?
Eight patients with psoriasis were given 200 mg caffeine orally with or without 1.2 mg kg^−1^ of 5‐methoxypsoralen. Blood and urine samples were collected over a 2‐day period. During 5‐methoxypsoralen coadministration, the apparent volume of distribution of caffeine remained unchanged, but oral clearance (CL~p.o.~) decreased from 9.5±3.8 (mean±s.d.) to 3.2±0.5 l h^−1^ (__P__<0.01). The area under the plasma concentration‐time curve (AUC) increased from 24±9 to 73±29 mg l^−1^ h (__P__<0.001). This decrease in CL~p.o.~ with increased AUC was consistent with a CYP1A2‐dependent inhibition of caffeine __N__‐demethylation which was further supported by significant decreases in the (AFMU+1U+1X)/17U and (AFMU+1U+1X)/17X urinary metabolic ratios.
Who reads Inhibition of Caffeine Metabolism by 5-Methoxypsoralen in Patients with Psoriasis?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- E. K. BENDRISS; Y. BECHTEL; A. BENDRISS; Ph. HUMBERT; G. PAINTAUD; J. MAGNETTE; P. AGACHE; P. R. BECHTEL
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0306-5251)
- Published
- 1996
- Language
- EN
- Field
- Medicine (Health Sciences)