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Can I read Investigating the potassium interactions with the palytoxin induced channels in Na+/K+ pump on EtoBox?
Investigating the potassium interactions with the palytoxin induced channels in Na+/K+ pump by Antônio M. Rodrigues; Antônio-Carlos G. Almeida; Antonio F.C. Infantosi; Hewerson Z. Teixeira; Mário A. Duarte is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Investigating the potassium interactions with the palytoxin induced channels in Na+/K+ pump about?
K + has been appointed as the main physiological inhibitor of the palytoxin (PTX) effect on the Na + /K + pump. This toxin acts opening monovalent cationic channels through the Na + /K + pump. We investigate, by means of computational modeling, the kinetic mechanisms related with K + interacting with the complex PTX-Na + /K + pump. First, a reaction model, with structure similar to Albers-Post model, describing the functional cycle of the pump, was proposed for describing K + interference on the complex PTX-Na + /K + pump in the presence of intracellular ATP. A mathematic model was derived from the reaction model and it was possible to solve numerically the associated differential equations and to simulate experimental maneuvers about the PTX induced currents in the presence of K + in the intra-and extracellular space as well as ATP in the intracellular. After the model adjusting to the experimental data, a Monte Carlo method for sensitivity analysis was used to analyze how each reaction parameter acts during each experimental maneuver involving PTX. For ATP and K + concentrations conditions, the simulations suggest that the enzyme substate with ATP bound to its high-affinity sites
Who reads Investigating the potassium interactions with the palytoxin induced channels in Na+/K+ pump?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Antônio M. Rodrigues; Antônio-Carlos G. Almeida; Antonio F.C. Infantosi; Hewerson Z. Teixeira; Mário A. Duarte
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 1476-9271)
- Published
- 2009
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)