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In vivo analysis of the post‐natal development of normal mouse brain by DTI by Pierre Larvaron; Odile Boespflug‐Tanguy; Jean‐Pierre Renou; Jean‐Marie Bonny is a Medicine article available to read on EtoBox.

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## Abstract The water diffusion characteristics of wild‐type mouse brains have been studied __in vivo__ by DTI to follow developmental changes. Here, axial (__λ__~//~) and radial (__λ__~⟂~) diffusivities and fractional anisotropy were measured from the fifth day of life (P5) and at three other post‐natal ages (P12, P19 and P54). Magnetic resonance images were collected from a single sagittal slice in the middle of the two hemispheres; ROI were chosen in nine different structures of both grey and white matter. Fractional anisotropy (FA) from P5 onwards distinguished structures of both white and grey matter, even though myelination had yet to occur. Between P5 and P54, a significant increase in FA was observed in the genu of the corpus callosum due to a significant decrease in __λ__~⟂~ whereas __λ__~//~ remained stable. Many other significant variations of __λ__~//~ and __λ__~⟂~ were measured in different structures. They were substantially correlated with axon and myelin maturation which are responsible for the main evolutions of the brain during its post‐natal development. These quantitative data show that __in vivo__ characterization of the anatomy and microstructure of the normal

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Author

Pierre Larvaron; Odile Boespflug‐Tanguy; Jean‐Pierre Renou; Jean‐Marie Bonny

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0952-3480)

Published

2006

Language

EN

Field

Medicine (Health Sciences)