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Wound-dressing Materials with Antibacterial Activity from Electrospun Gelatin Fiber Mats Containing Silver Nanoparticles by Pim-on Rujitanaroj; Nuttaporn Pimpha; Pitt Supaphol is a Materials Science article available to read on EtoBox.

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Ultrafine gelatin fiber mats with antibacterial activity against some common bacteria found on burn wounds were prepared from a gelatin solution (22%w/v in 70vol% acetic acid) containing 2.5wt% AgNO3. Silver nanoparticles (nAg), a potent antibacterial agent, first appeared in the AgNO3-containing gelatin solution after it had been aged for at least 12h, with the amount of nAg increasing with increasing aging time. The average diameters of the as-formed nAg ranged between 11 and 20nm. Electrospinning of both the base and the 12h-aged AgNO3-containing gelatin solutions resulted in the formation of smooth fibers, with average diameters of ∼230 and ∼280nm, respectively. The average diameter of the as-formed nAg in the electrospun fibers from the 12h-aged AgNO3-containing gelatin solution was ∼13nm. The nAg-containing gelatin fiber mats were further cross-linked with moist glutaraldehyde vapor to improve their stability in an aqueous medium. Both the weight loss and the water retention of the nAg-containing gelatin fiber mats in acetate buffer (pH 5.5), distilled water (pH 6.9) or simulated body fluid (SBF; pH 7.4) decreased with increasing cross-linking time. The release of Ag+ ions fr

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Author

Pim-on Rujitanaroj; Nuttaporn Pimpha; Pitt Supaphol

Publisher

Elsevier BV

Published

2008

Language

EN

Field

Materials Science (Physical Sciences)