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Can I read Decrypting the potential role of α-lipoic acid in Alzheimer's disease on EtoBox?
Decrypting the potential role of α-lipoic acid in Alzheimer's disease by Dapinder Kaur; Tapan Behl; Aayush Sehgal; Sukhbir Singh; Neelam Sharma; Sridevi Chigurupati; Ahmed Alhowail; Ahmed Abdeen; Samah F. Ibrahim; Celia Vargas-De-La-Cruz; Monika Sachdeva; Saurabh Bhatia; Ahmed Al-Harrasi; Simona Bungau is a Neuroscience article available to read on EtoBox.
What is Decrypting the potential role of α-lipoic acid in Alzheimer's disease about?
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases with motor disturbances, cognitive decline, and behavioral impairment. It is characterized by the extracellular aggregation of amyloid-β plaques and the intracellular accumulation of tau protein. AD patients show a cognitive decline, which has been associated with oxidative stress, as well as mitochondrial dysfunction. Alpha-lipoic acid (α-LA), a natural antioxidant present in food and used as a dietary supplement, has been considered a promising agent for the prevention or treatment of neurodegenerative disorders. Despite multiple preclinical studies indicating beneficial effects of α-LA in memory functioning, and pointing to its neuroprotective effects, to date only a few studies have examined its effects in humans. Studies performed in animal models of memory loss associated with aging and AD have shown that α-LA improves memory in a variety of behavioral paradigms. Furthermore, molecular mechanisms underlying α-LA effects have also been investigated. Accordingly, α-LA shows antioxidant, antiapoptotic, anti-inflammatory, glioprotective, metal chelating properties in both in vivo and in vitro studies
Who reads Decrypting the potential role of α-lipoic acid in Alzheimer's disease?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Dapinder Kaur; Tapan Behl; Aayush Sehgal; Sukhbir Singh; Neelam Sharma; Sridevi Chigurupati; Ahmed Alhowail; Ahmed Abdeen; Samah F. Ibrahim; Celia Vargas-De-La-Cruz; Monika Sachdeva; Saurabh Bhatia; Ahmed Al-Harrasi; Simona Bungau
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Neuroscience (Life Sciences)