Can I read Extracellular Vesicles as Next Generation Immunotherapeutics on EtoBox?

Extracellular Vesicles as Next Generation Immunotherapeutics by David W. Greening; Rong Xu; Anukreity Ale; Christoph E. Hagemeyer; Weisan Chen is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Extracellular Vesicles as Next Generation Immunotherapeutics about?

Extracellular vesicles (EVs) function as a mode of intercellular communication and molecular transfer to elicit diverse biological/functional response. Accumulating evidence has highlighted that EVs from immune, tumour, stromal cells and even bacteria and parasites mediate the communication of various immune cell types to dynamically regulate host immune response. EVs have an innate capacity to evade recognition, transport and transfer functional components to target cells, with subsequent removal by the immune system, where the immunological activities of EVs impact immunoregulation including modulation of antigen presentation and cross-dressing, immune activation, immune suppression, and immune surveillance, impacting the tumour immune microenvironment. In this review, we outline the recent progress of EVs in immunorecognition and therapeutic intervention in cancer, including vaccine and targeted drug delivery and summarise their utility towards clinical translation. We highlight the strategies where EVs (natural and engineered) are being employed as a therapeutic approach for immunogenicity, tumoricidal function, and vaccine development, termed immuno-EVs. With seminal studies p

Who reads Extracellular Vesicles as Next Generation Immunotherapeutics?

Author

David W. Greening; Rong Xu; Anukreity Ale; Christoph E. Hagemeyer; Weisan Chen

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)