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Prognostic Value of NT-proBNP After Ischemic Stroke: A Systematic Review and Meta-analysis of Prospective Cohort Studies by Yu-Hang Zhao; Hong Gao; Zhi-Yong Pan; Jie Li; Wen-Hong Huang; Ze-Fen Wang; Zhi-Qiang Li is a Medicine article available to read on EtoBox.

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## Background: Many studies have evaluated the relationship between n-terminal pro-brain natriuretic peptide (nt-probnp) and its prognostic value in ischemic stroke. however, a widespread consensus has not been reached. therefore, we completed a meta-analysis to evaluate the prognostic significance of nt-probnp for mortality and functional outcome in patients with ischemic stroke. ## Methods: We performed a systematic search and review using the pubmed and embase databases to identify literature that reported a correlation between nt-probnp and mortality and functional outcome in ischemic stroke patients. ## Results: Eleven studies inclusive of 10,498 patients met the inclusion criteria. elevated plasma nt-probnp levels were associated with increased risk of mortality in ischemic stroke patients (all-cause mortality: odds ratio [or] = 2.43, 95% confidence interval [ci] 1.62-3.64, p < .001, i=74.3%; cardiovascular mortality: or = 2.01, 95% ci 1.55-2.61, p < .001, i = 42.6%). in addition, unfavorable functional outcomes were observed in patients with higher levels of nt-probnp (or = 1.68, 95% ci 1.13-2.50, p = .01, i = 90.8%) after ischemic stroke. ## Conclusions: This meta-analysis

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Author

Yu-Hang Zhao; Hong Gao; Zhi-Yong Pan; Jie Li; Wen-Hong Huang; Ze-Fen Wang; Zhi-Qiang Li

Publisher

Elsevier Science; Elsevier ; W. B. Saunders Co., Ltd.; Elsevier BV (ISSN 1532-8511)

Published

2020

Language

EN

Field

Medicine (Health Sciences)