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Promoting angiogenesis and diabetic wound healing through delivery of protein transduction domain-BMP2 formulated nanoparticles with hydrogel by Jae Wan Suh; Kyoung-Mi Lee; Eun Ae Ko; Dong Suk Yoon; Kwang Hwan Park; Hyun Sil Kim; Jong In Yook; Nam Hee Kim; Jin Woo Lee is a Medicine article available to read on EtoBox.
What is Promoting angiogenesis and diabetic wound healing through delivery of protein transduction domain-BMP2 formulated nanoparticles with hydrogel about?
Decreased angiogenesis contributes to delayed wound healing in diabetic patients. Recombinant human bone morphogenetic protein-2 (rhBMP2) has also been demonstrated to promote angiogenesis. However, the short half-lives of soluble growth factors, including rhBMP2, limit their use in wound-healing applications. To address this limitation, we propose a novel delivery model using a protein transduction domain (PTD) formulated in a lipid nanoparticle (LNP). We aimed to determine whether a gelatin hydrogel dressing loaded with LNP-formulated PTD-BMP2 (LNP-PTD-BMP2) could enhance the angiogenic function of BMP2 and improve diabetic wound healing. In vitro, compared to the control and rhBMP2, LNP-PTD-BMP2 induced greater tube formation in human umbilical vein endothelial cells and increased the cell recruitment capacity of HaCaT cells. We inflicted large, full-thickness back skin wounds on streptozotocin-induced diabetic mice and applied gelatin hydrogel (GH) cross-linked by microbial transglutaminase containing rhBMP2, LNP-PTD-BMP2, or a control to these wounds. Wounds treated with LNP-PTD-BMP2-loaded GH exhibited enhanced wound closure, increased re-epithelialization rates, and higher c
Who reads Promoting angiogenesis and diabetic wound healing through delivery of protein transduction domain-BMP2 formulated nanoparticles with hydrogel?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Jae Wan Suh; Kyoung-Mi Lee; Eun Ae Ko; Dong Suk Yoon; Kwang Hwan Park; Hyun Sil Kim; Jong In Yook; Nam Hee Kim; Jin Woo Lee
- Publisher
- SAGE Publications
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)