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Can I read Karyotype in myelodysplastic syndromes: Relations to morphology, clinical evolution, and survival on EtoBox?
Karyotype in myelodysplastic syndromes: Relations to morphology, clinical evolution, and survival by Dr. P. Bernasconi; E. P. Alessandrino; M. Boni; M. Bonfichi; E. Morra; M. Lazzarino; C. Campagnoli; C. Astori is a Medicine article available to read on EtoBox.
What is Karyotype in myelodysplastic syndromes: Relations to morphology, clinical evolution, and survival about?
One hundred eighty-eight unselected consecutive patients with "de novo" myelodysplastic syndrome (MDS) were studied cytogenetically. They were subclassified as 4 refractory anemia with ringed sideroblasts (RARS), 67 refractory anemia (RA), 58 refractory anemia with excess of blasts (RAEB), 40 RAE6 in transformation (RAEB-t), and 19 chronic myelomonocytic leukemia (CMML). The overall incidence of chromosome abnormalities was 69%. The RAEB and RAEB-t patients showed karyotypic changes, more often than RA and CMML (76% and 100% vs. 56% and 42%, respectively). The most frequent single anomaly was de1(5)(q13-q22q33) (22 cases), followed by monosomy 7 or del 7q (11 cases), del(l1) (q14q23) (8 cases), trisomy 8 (4 cases). Complex karyotypes (defined by the presence of three or more structural or numerical abnormalities) were detected in 33 patients. With regard to the FAB classification, del (5)(q13q33) was associated with RA, and complex rearrangements with RAE6 and RAEB-t. Leukemic transformation occurred in 66 patients (46%), none with a normal karyotype or del(1 l)(q14q23) as single abnormality. In patients carrying 5q-alone, acute evolution correlated with proximal breakpoint localiz
Who reads Karyotype in myelodysplastic syndromes: Relations to morphology, clinical evolution, and survival?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Dr. P. Bernasconi; E. P. Alessandrino; M. Boni; M. Bonfichi; E. Morra; M. Lazzarino; C. Campagnoli; C. Astori
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0361-8609)
- Published
- 1994
- Language
- EN
- Field
- Medicine (Health Sciences)