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Mismatch between BDNF mRNA and protein expression in the developing visual cortex: the role of visual experience by Daniela Tropea; Simona Capsoni; Enrico Tongiorgi; Sabina Giannotta; Antonino Cattaneo; Luciano Domenici is a Neuroscience article available to read on EtoBox.
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## Abstract Brain‐derived neurotrophic factor (BDNF) messenger RNA (mRNA) expression in the rat visual cortex of young and postnatal day 90 (P90) animals is developmentally regulated and influenced by visual experience. In the present paper we compared the expression of BDNF mRNA to the actual changes of BDNF protein occurring during postnatal development and verified whether BDNF protein distribution is controlled by visual activity. To achieve this aim we analysed BDNF mRNA and/or BDNF protein cellular distribution in the rat visual cortex at different postnatal ages by using immunohistochemistry and highly sensitive __in situ__ hybridization. We found that before eye opening (P13), in all cortical layers a large number of visual cortical neurons contain BDNF mRNA with no detectable amount of BDNF protein. At later ages (P23 and P90), the number of BDNF‐immunostained cells increases; most neurons are double labelled for BDNF mRNA and protein, and a small group of neurons is labelled only for BDNF protein. The cellular increase of BDNF immunolabelling is blocked in animals deprived of visual experience from birth (dark rearing), with a large population of neurons containing BDNF m
Who reads Mismatch between BDNF mRNA and protein expression in the developing visual cortex: the role of visual experience?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Daniela Tropea; Simona Capsoni; Enrico Tongiorgi; Sabina Giannotta; Antonino Cattaneo; Luciano Domenici
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0953-816X)
- Published
- 2001
- Language
- EN
- Field
- Neuroscience (Life Sciences)