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Dexmedetomidine Withdrawal Syndrome in Children in the PICU: Systematic Review and Meta-Analysis by Thomas Knapp; Olivia DiLeonardo; Tim Maul; Alexander Hochwald; Zhuo Li; Jobayer Hossain; Adam Lowry; Jason Parker; Kimberly Baker; Peter Wearden; Jennifer Nelson is a scholarly article available to read on EtoBox.

What is Dexmedetomidine Withdrawal Syndrome in Children in the PICU: Systematic Review and Meta-Analysis about?

## Objectives: To systematically review literature describing the clinical presentation, risk factors, and treatment for dexmedetomidine withdrawal in the PICU (PROSPERO: CRD42022307178). ## Data Sources: MEDLINE/PubMed, Cochrane, Web of Science, and Scopus databases were searched. ## Study Selection: Eligible studies were published from January 2000 to January 2022 and reported clinical data for patients younger than 21 years old following discontinuation of dexmedetomidine after greater than or equal to 24 hours of infusion. ## Data Extraction: Abstracts identified during an initial search were screened and data were manually abstracted after full-text review of eligible articles. The Newcastle-Ottawa Scale was used to assess study quality. Summary statistics were provided and Spearman rank correlation coefficient was used to identify relationships between covariates and withdrawal signs. A weighted prevalence for each withdrawal sign was generated using a random-effects model. ## Data Synthesis: Twenty-three studies (22 of which were retrospective cohort studies) containing 28 distinct cohorts were included. Median cumulative dexmedetomidine exposure by dose was 105.95 μg/kg (ra

Author

Thomas Knapp; Olivia DiLeonardo; Tim Maul; Alexander Hochwald; Zhuo Li; Jobayer Hossain; Adam Lowry; Jason Parker; Kimberly Baker; Peter Wearden; Jennifer Nelson

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2023