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Application of κ Free Light Chains in Cerebrospinal Fluid as a Biomarker in Multiple Sclerosis Diagnosis: Development of a Diagnosis Algorithm by Estefania Valencia-Vera; Ana Martinez-Escribano Garcia-Ripoll; Alfredo Enguix; Carmen Abalos-Garcia; Maria Jesus Segovia-Cuevas is a scholarly article available to read on EtoBox.

What is Application of κ Free Light Chains in Cerebrospinal Fluid as a Biomarker in Multiple Sclerosis Diagnosis: Development of a Diagnosis Algorithm about?

## Abstract ## Background: The determination of κ free light chains (KFLC) in cerebrospinal fluid (CSF) by nephelometry is a feasible alternative to immunoglobulin G oligoclonal bands (OCB) in the evaluation of intrathecal synthesis of immunoglobulin in multiple sclerosis (MS) and other demyelinating diseases. The aim of this study was to assess the diagnostic value of KFLC and its inclusion in a procedure algorithm along with OCB interpretation. ## Methods: A cross-sectional study, which included 123 patients with a CSF OCB request, was carried out. Isoelectric focusing followed by immunofixation was used to detect OCB, and nephelometry was used to analyze KFLC. The KFLC index was calculated using CSF/serum quotient of KFLC and albumin. The KFLC index was compared with MS diagnosis to find the optimal cutoff. It was obtained from the receiver operating characteristic (ROC) curves and the Youden method. ## Results: The CSF KFLC median was 1.66 mg/L in the MS group, whereas in other central nervous system diseases, KFLC showed generally no or only moderate increase in CSF (median 0.10 mg/L). KFLC index showed a significant difference between groups. ROC analysis for CSF KFLC concent

Author

Estefania Valencia-Vera; Ana Martinez-Escribano Garcia-Ripoll; Alfredo Enguix; Carmen Abalos-Garcia; Maria Jesus Segovia-Cuevas

Publisher

Walter de Gruyter GmbH

Published

2017

Language

EN