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The Impact of Mutations in Sars-Cov-2 Spike On Viral Infectivity and Antigenicity by John Matthew Gicom is a document available to read on EtoBox.
This study analyzed over 100 natural variants and engineered mutants of the SARS-CoV-2 spike protein to understand their impact on viral infectivity and interaction with neutralizing antibodies. They found that the dominant D614G variant and some variants containing D614G were more infectious. Mutations in the receptor binding domain generally reduced infectivity, but some variants showed resistance to neutralizing antibodies. Deletion of two glycosylation sites drastically reduced infectivity, demonstratin
- Author
- John Matthew Gicom
- Language
- EN