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## Abstract | I. | Introduction | 370 | | II. | Techniques That Are Usually Employed in the Study of Bioorganic Macromolecules | 371 | | | A. Proteins and Peptides | 371 | | | B. Oligonucleotides | 374 | | | C. Oligosaccharides and Glycoconjugates | 375 | | | D. Various Complexes (DNA–Protein, Antigen–Antibody, Macromolecules–Metals) | 377 | | III. | Common Problems and Developments in the Analysis of Bioorganic Macromolecules by Mass Spectrometry | 377 | | | A. Ionization Source Problems and Developments | 377 | | | 1. Sensitivity | 377 | | | 2. Problems with Buffers | 379 | | | 3. Multicharge Effect | 381 | | | B. Mass Analyzer Problems and Developments | 381 | | | 1. Linear Dynamic Range | 381 | | | 2. Tandem Mass Spectrometry | 382 | | | 3. Sensitivity | 382 | | | 4. Resolution | 383 | | | 5. Mass Accuracy | 383 | | IV. | New Promising Technologies | 384 | | | A. Interfaces and Ionization Sources | 384 | | | 1. Improvements in the Coupling of Liquid‐Phase Separation Systems to Mass Spectrometry | 384 | | | 2. AP‐MALDI | 384 | | | 3. Deprotonant Agents | 385 | | | 4. Sonic Spray Ionization | 388 |

Author

Simone Cristoni; Luigi Rossi Bernardi

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0277-7037)

Published

2003

Language

EN