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Asymptotic forms of tracer clearance curves: Theory and applications of improved extrapolations by Ludvik Bass; Janet Aisbett; Anthony J. Bracken is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Tracer clearance curves are conventionally extrapolated beyond times of observation by using monoexponential asymptotic forms. The inadequacy of the resulting predictions, especially as to the mean transit time and quantities derived from it, has been previously demonstrated experimentally. Here improvements in extrapolations and in the resulting predictions are derived theoretically and tested on previously published data, venous as well as externally recorded. First, secure lower bounds on the mean transit times are constructed, and shown to be much higher than conventional outright estimates for venous data (twice as high in some cases). Next, new asymptotic forms of tracer clearance curves from kinetically heterogeneous systems are derived; they are not monoexponential, but they are as robust, contain as few parameters and are as easily connected to data. It is shown theoretically that for real organs these new asymptotic forms should extrapolate and predict better than monoexponentials, and this is demonstrated on previously published venous data from perfused muscle. In particular, the resulting outright predictions of mean transit times are substantially better than the best

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Author

Ludvik Bass; Janet Aisbett; Anthony J. Bracken

Publisher

Elsevier Science; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 0022-5193)

Published

1984

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)