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A Temporal and Spatial Map of Axons in Developing Mouse Prostate by Turco, Anne E.; Cadena, Mark T.; Zhang, Helen L.; Sandhu, Jaskiran K.; Oakes, Steven R.; Chathurvedula, Thrishna; Peterson, Richard E.; Keast, Janet R.; Vezina, Chad M. is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is A Temporal and Spatial Map of Axons in Developing Mouse Prostate about?

Prostate autonomic and sensory axons control glandular growth, fluid secretion, and smooth muscle contraction and are remodeled during cancer and inflammation. Morphogenetic signaling pathways reawakened during disease progression may drive this axon remodeling. These pathways are linked to proliferative activities in prostate cancer and benign prostate hyperplasia. However, little is known about which developmental signaling pathways guide axon investment into prostate. The first step in defining these pathways is pinpointing when axon subtypes first appear in prostate. We accomplished this by immunohistochemically mapping three axon subtypes (noradrenergic, cholinergic, and peptidergic) during fetal, neonatal, and adult stages of mouse prostate development. We devised a method for peri-prostatic axon density quantification and tested whether innervation is uniform across the proximo-distal axis of dorsal and ventral adult mouse prostate. Many axons directly interact with or innervate neuroendocrine cells in other organs, so we examined whether sensory or autonomic axons innervate neuroendocrine cells in prostate. We first detected noradrenergic, cholinergic, and peptidergic axons

Who reads A Temporal and Spatial Map of Axons in Developing Mouse Prostate?

Author

Turco, Anne E.; Cadena, Mark T.; Zhang, Helen L.; Sandhu, Jaskiran K.; Oakes, Steven R.; Chathurvedula, Thrishna; Peterson, Richard E.; Keast, Janet R.; Vezina, Chad M.

Publisher

Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 1432-119X)

Published

2019

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)