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Can I read Correlation of C-myc Overexpression and Amplification with Progression of Preneoplastic Liver Lesions to Malignancy in the Poorly Susceptible Wistar Rat Strain on EtoBox?
Correlation of C-myc Overexpression and Amplification with Progression of Preneoplastic Liver Lesions to Malignancy in the Poorly Susceptible Wistar Rat Strain by Maria R. De Miglio; Maria M. Simile; Maria R. Muroni; Stefano Pusceddu; Diego Calvisi; Angelo Carru; Maria A. Seddaiu; Lucia Daino; Luca Deiana; Rosa M. Pascale; Francesco Feo is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Correlation of C-myc Overexpression and Amplification with Progression of Preneoplastic Liver Lesions to Malignancy in the Poorly Susceptible Wistar Rat Strain about?
Persistent liver nodules (PNs) and hepatocellular carcinomas (HCCs) induced in F344 rats by the resistant hepatocyte (RH) model exhibit c-myc overexpression and amplification. The role of these changes in progression of PN was investigated in nodules with different propensities to evolve to HCC in resistant Wistar rats and, for comparison, in susceptible F344 rats. Initiation of rats with diethylnitrosamine was followed by selection with 2-acetylaminofluorene (AAF) plus partial hepatectomy (RH groups). Two additional Wistar rat groups received a second AAF treatment without (RH+AAF) and with a necrogenic dose of CCl4 (RH+AAF/CCl4) 15 d after selection. The number to liver ratio and volume of glutathione-s-transferase placental form-positive lesions were lower in the Wistar than the F344 RH groups 9 and 32 wk after initiation and increased after a second AAF cycle treatment with and without CCl4. DNA synthesis in glutathione-s-transferase placental form-positive lesions was low in Wistar RH group at 9 wk and was stimulated by additional AAF treatments. HCCs developed at 57-60 wk in F344 RH, Wistar RH+AAF, and RH+AAF/CCl4 rats. Tumor incidence and multiplicity were lower in RH+AAF ra
Who reads Correlation of C-myc Overexpression and Amplification with Progression of Preneoplastic Liver Lesions to Malignancy in the Poorly Susceptible Wistar Rat Strain?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Maria R. De Miglio; Maria M. Simile; Maria R. Muroni; Stefano Pusceddu; Diego Calvisi; Angelo Carru; Maria A. Seddaiu; Lucia Daino; Luca Deiana; Rosa M. Pascale; Francesco Feo
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0899-1987)
- Published
- 1999
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)