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Mechanical modulation of tenascin-C and collagen-XII expression during avian synovial joint formation by Borjana Mikic; Marcy Wong; Matthias Chiquet; Ernst B. Hunziker is a Medicine article available to read on EtoBox.

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## Abstract The objective of this study was to investigate how temporal and spatial patterns of characteristic extracellular matrix molecules are altered in the absence of normal functional skeletal muscle contractions during avian synovial joint development. By using __in situ__ detection of protein and mRNA expression in developing avian feet and femorotibial joints from a wide range of developmental stages, we demonstrate that the morphological abnormalities that result from embryonic immobilization are associated with altered patterns of tenascin‐C and collagen‐XII expression within developing joint structures. As the joints fuse in immobilized embryos, the cells of the presumptive articular surface differentiate from flattened fibroblasts to more rounded chondrocytes and collagens XII and I are no longer detected at sites of complete joint fusion. Although the expression of collagen XII persists at normal levels elsewhere within the immobilized joint, tenascin‐C expression is diminished within the chondroepiphysis, synovium, and tendons, as well as within the remains of the fibrous articular surface. This effect is most notable for the shortest tenascin variant (Tn 190) within

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Author

Borjana Mikic; Marcy Wong; Matthias Chiquet; Ernst B. Hunziker

Publisher

Elsevier Science; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley (ISSN 0736-0266)

Published

2000

Language

EN

Field

Medicine (Health Sciences)