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Protein Binding of Mercury in Milk and Plasma from Mice and Man — a Comparison Between Methylmercury and Inorganic Mercury by Johanna Sundberg; Bo Ersson; Bo Lönnerdal; Agneta Oskarsson is a Environmental Science article available to read on EtoBox.

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Inorganic mercury has previously been shown to be excreted to milk from plasma to a higher extent than methylmercury. Protein binding of mercury as methylmercury and inorganic mercury in whey and plasma from mouse and man was studied in order to get a better understanding of the transport of mercury into milk. Mice were administered a single i.v. dose of 0.25 mg Hg/kg body weight labelled with CH 3 203 HgCl or 203 HgCl 2 , resulting in 11 ng Hg/g milk and 38 ng Hg/g milk after 1 h, respectively. Milk and plasma from mice and man were also incubated with the respective radiolabelled compound (150 ng Hg/g milk or plasma). Casein, fat and whey fractions in milk from methylmercury treated mice were found to contain 11, 39 and 34%, respectively, and from inorganic mercury treated mice 31, 15 and 41%, respectively, of the total amount of mercury in milk. Serum albumin was a major mercury binding protein in whey and plasma from mice for both methylmercury and inorganic mercury, as demonstrated by FPLC gel filtration and anion-exchange chromatography and further characterised by SDS-PAGE for whey. In addition, anion-exchange chromatography indicated that inorganic mercury, but not methylme

Who reads Protein Binding of Mercury in Milk and Plasma from Mice and Man — a Comparison Between Methylmercury and Inorganic Mercury?

Author

Johanna Sundberg; Bo Ersson; Bo Lönnerdal; Agneta Oskarsson

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0300-483X)

Published

1999

Language

EN

Field

Environmental Science (Life Sciences)