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Serotypic evolution of measles virus is constrained by multiple co-dominant B cell epitopes on its surface glycoproteins by Muñoz-Alía, Miguel Ángel (author);Nace, Rebecca A. (author);Zhang, Lianwen (author);Russell, Stephen J. (author) is a Medicine article available to read on EtoBox.
What is Serotypic evolution of measles virus is constrained by multiple co-dominant B cell epitopes on its surface glycoproteins about?
## Summary After centuries of pestilence and decades of global vaccination, measles virus (MeV) genotypes capable of evading vaccine-induced immunity have not emerged. Here, by systematically building mutations into the hemagglutinin (H) glycoprotein of an attenuated measles virus strain and assaying for serum neutralization, we show that virus evolution is severely constrained by the existence of numerous co-dominant H glycoprotein antigenic sites, some critical for binding to the pathogenicity receptors SLAMF1 and nectin-4. We further demonstrate the existence in serum of protective neutralizing antibodies targeting co-dominant fusion (F) glycoprotein epitopes. Lack of a substantial reduction in serum neutralization of mutant measles viruses that retain even one of the co-dominant antigenic sites makes evolution of pathogenic measles viruses capable of escaping serum neutralization in vaccinated individuals extremely unlikely.
Who reads Serotypic evolution of measles virus is constrained by multiple co-dominant B cell epitopes on its surface glycoproteins?
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- Author
- Muñoz-Alía, Miguel Ángel (author);Nace, Rebecca A. (author);Zhang, Lianwen (author);Russell, Stephen J. (author)
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)