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Hydrophobic Bombyx mori Silk Fibroin: Routes to Functionalization with Alkyl Chains by Giorgio Rizzo; Carola Ricciardelli; Eloisa Sardella; Roberta Musio; Marco Lo Presti; Danilo Vona; Fiorenzo G. Omenetto; Gianluca Maria Farinola is a Materials Science article available to read on EtoBox.

What is Hydrophobic Bombyx mori Silk Fibroin: Routes to Functionalization with Alkyl Chains about?

## Abstract __Bombyx mori__ silk fibroin (SF) is a very versatile biopolymer due to its biocompatibility and exceptional mechanical properties which make possible its use as a functional material in several applications. SF can be modified with a large variety of chemical approaches which endow the material with tailored chemical–physical properties. Here, a systematic investigation of different routes is reported to graft long alkyl chains on SF based on both liquid‐ and solid‐phase, aiming to modulate its hydrophobic behavior. The liquid phase method involves direct activation of SF tyrosine residues via diazo coupling and cycloaddition reactions, generating hydrophobic materials insoluble in any common solvent. The solid phase approach consists of the chemical modification of drop‐casted SF films by esterification of hydroxyl groups of serine, threonine, and tyrosine SF residues with acyl chlorides of fatty acids. For the solid‐state functionalization, a new class of hydrophobic pendant groups is synthesized, based on triple esters of gallic acid anhydrides, that are reacted with the biopolymer to further enhance its resulting hydrophobic features.

Who reads Hydrophobic Bombyx mori Silk Fibroin: Routes to Functionalization with Alkyl Chains?

Author

Giorgio Rizzo; Carola Ricciardelli; Eloisa Sardella; Roberta Musio; Marco Lo Presti; Danilo Vona; Fiorenzo G. Omenetto; Gianluca Maria Farinola

Publisher

Wiley

Published

2023

Language

EN

Field

Materials Science (Physical Sciences)