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Limbal Stem-Cell Expansion and Transplantation by Paolo Rama; Stanislav Matuska; Graziella Pellegrini is a book available to read on EtoBox.

What is Limbal Stem-Cell Expansion and Transplantation about?

Limbal stem-cell transplantation is indicated for treating a corneal epithelial stem-cell disorder known as limbal stem-cell defi ciency (LSCD). Lamellar and/or penetrating keratoplasty cannot be used successfully in these cases as donor corneal epithelium is replaced by that of the recipient within months. In the presence of corneal epithelial stem-cell compartment defi ciency, donor graft reepithelialization will not take place, with subsequent epithelial defects and the ultimate recurrence of conjunctivalization and the risk of rejection and failure. Unilateral limbal stemcell defi ciency has been successfully treated for years by directly grafting a portion of the healthy limbal tissue taken from the contralateral eye, but some concerns exist regarding potential donor eye risks. To overcome risks for the donor eye, a technique to reduce biopsy dimension using cell expansion in culture has been developed. Autologous cultivated limbal stem-cell transplantation is an effective and safe procedure to treat limbal stem-cell defi ciency when there is an undamaged, even small, portion of the limbus that will provide donor cells to be expanded in vitro. Ex vivo limbal grafts have severa

Author

Paolo Rama; Stanislav Matuska; Graziella Pellegrini

Publisher

Springer International Publishing ; Imprint Springer, Springer International Publishing. Springer International Publishing, Imprint Springer : Springer International Publishing

Published

2015

Language

EN

ISBN

9783319240527

Subjects

Medical, Medicine

Updated

2026-03-24