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Can I read Tumour Budding and Poorly Differentiated Clusters in Colon Cancer – Different Manifestations of Partial Epithelial–mesenchymal Transition on EtoBox?
Tumour Budding and Poorly Differentiated Clusters in Colon Cancer – Different Manifestations of Partial Epithelial–mesenchymal Transition by Ana Pavlič; Emanuela Boštjančič; Rajko Kavalar; Bojan Ilijevec; Serena Bonin; Fabrizio Zanconati; Nina Zidar is a Medicine article available to read on EtoBox.
What is Tumour Budding and Poorly Differentiated Clusters in Colon Cancer – Different Manifestations of Partial Epithelial–mesenchymal Transition about?
## Abstract Morphological features including infiltrative growth, tumour budding (TB), and poorly differentiated clusters (PDCs) have a firmly established negative predictive value in colorectal cancer (CRC). Despite extensive research, the mechanisms underlying different tumour growth patterns remain poorly understood. The aim of this study was to investigate the involvement of epithelial–mesenchymal transition (EMT) in TB and PDCs in CRC. Using laser‐capture microdissection, we obtained distinct parts of the primary CRC including TB, PDCs, expansive tumour front, and the central part of the tumour, and analysed the expression of EMT‐related markers, i.e. the __miR‐200__ family, __ZEB1/2__, __RND3__, and __CDH1__. In TB, the __miR‐200__ family and __CDH1__ were significantly downregulated, while __ZEB2__ was significantly upregulated. In PDCs, __miR‐141__, __miR‐200c__, and __CDH1__ were significantly downregulated__.__ No significant differences were observed in the expression of any EMT‐related markers between the expansive tumour front and the central part of the tumour. Our results suggest that both TB and PDCs are related to partial EMT. Discrete differences in morphology and
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- Author
- Ana Pavlič; Emanuela Boštjančič; Rajko Kavalar; Bojan Ilijevec; Serena Bonin; Fabrizio Zanconati; Nina Zidar
- Publisher
- Wiley
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)