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Structural and Functional Optimisation of Lomustine Through Hydroxypropyl - Cyclodextrin Complexation: in Vitro and Computational Insights by anh.nguyenvan is a document available to read on EtoBox.
What is Structural and Functional Optimisation of Lomustine Through Hydroxypropyl - Cyclodextrin Complexation: in Vitro and Computational Insights about?
The study investigates the use of hydroxypropyl-β-cyclodextrin (HPβCD) to enhance the solubility and therapeutic efficacy of lomustine (LMT), a poorly soluble anticancer drug. Results show that the HPβCD complex significantly improves dissolution properties and anticancer activity against U87-MG glioblastoma cells, with in vitro studies indicating reduced cell viability for the complexed formulations. The findings suggest that HPβCD complexation is a promising strategy for improving glioblastoma treatment o
- Author
- anh.nguyenvan
- Language
- EN