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Digitalis glycosides are no longer considered first-line treatment for heart failure but are discussed due to their history of use. Digoxin is the prototype agent that comes from foxglove plants and has an oral bioavailability of 70% and half-life of 36 hours. It works by inhibiting sodium-potassium ATPase pumps, increasing intracellular calcium levels and contractility. While it can improve heart failure symptoms, it does not prolong life. Its use for atrial fibrillation aims to slow ventricular rate. Toxi

Author

pathan mohid

Language

EN