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Interaction of cyclosporin A with 1,2-dimyristoyl-sn-glycero-3-phosphocholine unilamellar vesicles studied by electron spin resonance by Lidija Stuhne-Sekalec; Nikola Z. Stanacev is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Interaction of cyclosporin A with 1,2-dimyristoyl-sn-glycero-3-phosphocholine unilamellar vesicles studied by electron spin resonance about?

Thermally induced changes of unilamellar 1,2-dimyristoyl-sn-giycero-3-phosphocholine (DMPC) liposomes and DMPC liposomes containing cyclosporin A (CsA) were studied by electron spin resonance (ESR) spectroscopy with 5-, 12-or 16-nitroxide stearic acid (NO-SA) as probes. All liposomes were purified by Sepharose 4B column chromatography and the amount of CsA associated with these liposomes was determined. The results obtained established that the temperature range of the gel-to-liquid crystalline phase transition of liposomes does not broaden significantly in the presence of CsA. In addition, the order of parameters of these fiposomes obtained with 5-NO-SA as a probe showed no significant influence of CsA. It was concluded that CsA does not interact with the hydrocarbon region of DMPC liposomes but resides exclusively within the aqueous compartment of liposomes.

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Author

Lidija Stuhne-Sekalec; Nikola Z. Stanacev

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0009-3084)

Published

1988

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)