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Metabonomics investigation of human urine after ingestion of green tea with gas chromatography/mass spectrometry, liquid chromatography/mass spectrometry and ^1^H NMR spectroscopy by Wai Siang Law; Pei Yun Huang; Eng Shi Ong; Choon Nam Ong; Sam Fong Yau Li; Kishore Kumar Pasikanti; Eric Chun Yong Chan is a Chemistry article available to read on EtoBox.
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## Abstract A method using gas chromatography/mass spectrometry (GC/MS), liquid chromatography/mass spectrometry (LC/MS) and ^1^H NMR with pattern recognition tools such as principle components analysis (PCA) was used to study the human urinary metabolic profiles after the intake of green tea. From the normalized peak areas obtained from GC/MS and LC/MS and peak heights from ^1^H NMR, statistical analyses were used in the identification of potential biomarkers. Metabolic profiling by GC/MS provided a different set of quantitative signatures of metabolites that can be used to characterize the molecular changes in human urine samples. A comparison of normalized metabonomics data for selected metabolites in human urine samples in the presence of potential overlapping peaks after tea ingestion from LC/MS and ^1^H NMR showed the reliability of the current approach and method of normalization. The close agreements of LC/MS with ^1^H NMR data showed that the effects of ion suppression in LC/MS for early eluting metabolites were not significant. Concurrently, the specificity of detecting the stated metabolites by ^1^H NMR and LC/MS was demonstrated. Our data showed that a number of metabol
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- Author
- Wai Siang Law; Pei Yun Huang; Eng Shi Ong; Choon Nam Ong; Sam Fong Yau Li; Kishore Kumar Pasikanti; Eric Chun Yong Chan
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0951-4198)
- Published
- 2008
- Language
- EN
- Field
- Chemistry (Physical Sciences)