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Investigation of Tryptase Gene Composition as a Potential Biomarker of Food Allergy Reaction Severity by Abigail Lang; Stephanie Kubala; Pamela Guerrerio; Jacqueline Pongracic; Rajesh Kumar; Jonathan Lyons is a Medicine article available to read on EtoBox.

What is Investigation of Tryptase Gene Composition as a Potential Biomarker of Food Allergy Reaction Severity about?

RATIONALE: Japan is one of the few countries that legally prohibits precautionary allergen labelling (PAL) by establishing official methods for detecting the protein of allergenic ingredients (allergens) and setting the threshold of protein content for the national labeling system. This study was conducted to develop the quantitative risk-assessment methods for allergic-reactions to foods containing allergenic ingredients and to verify the validity of the evaluation criteria of Japan's food allergy-labeling system. METHODS: Bayesian model averaging statistical analysis was used to estimate the probability of allergic-reactions among various Japanese individuals with food allergies. The distribution of unintended allergen concentration and portion size of each food was estimated based on previous public data and practical results measured using ELISA in foods without the labeling, and the exposure doses were calculated by multiplying these two distributions using MonteCarlo simulation. A probabilistic quantitative risk-assessment was conducted by integrating the product of the probability density function of the allergen-exposure and the cumulative distribution function of the thres

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Author

Abigail Lang; Stephanie Kubala; Pamela Guerrerio; Jacqueline Pongracic; Rajesh Kumar; Jonathan Lyons

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Medicine (Health Sciences)