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Regulation of αvβ3 and α5β1 integrin receptors by basic fibroblast growth factor and platelet‐derived growth factor‐BB in intrasynovial flexor tendon cells by Frederick L Harwood; Randal S Goomer; Richard H Gelberman; Matthew J Silva; David Amiel is a Medicine article available to read on EtoBox.
What is Regulation of αvβ3 and α5β1 integrin receptors by basic fibroblast growth factor and platelet‐derived growth factor‐BB in intrasynovial flexor tendon cells about?
Integrins are important players in soft tissue healing as molecules that mediate communication between cells and extracellular matrix. Thus, the regulation of the expression of these molecules would be important during wound repair. To explore the regulatory roles of specific growth factors on integrin expression by intrasynovial flexor tendon cells, the present study assessed the in vitro effects of basic fibroblast growth factor and platelet derived growth factor‐BB on expression of the α5β1 and αvβ3 integrins in these cells. Analyses were carried out at the transcriptional (reverse transcription‐polymerase chain reaction) and translational (immunohistochemistry) levels of cellular metabolism. Both types of analyses revealed increased expression of α5β1 and αvβ3 by tendon cells exposed to either basic fibroblast growth factor or platelet‐derived growth factor‐BB over a wide range of growth factor concentrations employed in the study. Semiquantitative reverse transcription‐polymerase chain reaction showed that, relative to control, basic fibroblast growth factor and platelet‐derived growth factor‐BB increased the expression of αv mRNA by 2‐and 3‐fold, respectively. Alpha 5 mRNA ex
Who reads Regulation of αvβ3 and α5β1 integrin receptors by basic fibroblast growth factor and platelet‐derived growth factor‐BB in intrasynovial flexor tendon cells?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Frederick L Harwood; Randal S Goomer; Richard H Gelberman; Matthew J Silva; David Amiel
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1067-1927)
- Published
- 1999
- Language
- EN
- Field
- Medicine (Health Sciences)