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Methods for the Synthesis of Carbon-13 Labelled Acids and Esters by Angela C. Jordan; Lorraine C. Axford; John R. Harding; Yvonne O'Connell; Thomas J. Simpson; Christine L. Willis is a scholarly article available to read on EtoBox.

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## Abstract Syntheses of isotopically labelled putative biosynthetic intermediates to the natural products monocerin **1**, hectochlorin **2** and strobilurin A **3** are described. For the preparation of [9,10‐^13^C~2~]dihydroisocoumarin **10**, a stereoselective aldol condensation of ^13^C~2~‐acetylated chiral auxiliary **5** was used to assemble the labelled C9‐C14 fragment. The preferred approaches to the syntheses of [1,2‐^13^C~2~]5,5‐dichlorohexanoic acid **15** and the __N__‐acetylcysteamine derivative of [1,2‐^13^C~2~]cinnamic acid **19** involved a Horner‐Wadsworth‐Emmons chain extension and Knoevenagel reaction, respectively. Copyright © 2007 John Wiley & Sons, Ltd.

Author

Angela C. Jordan; Lorraine C. Axford; John R. Harding; Yvonne O'Connell; Thomas J. Simpson; Christine L. Willis

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-2135)

Published

2007

Language

EN