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Effectiveness and Safety of Nizatidine, 75 Mg, for the Relief of Episodic Heartburn by K. Paul; C. M. Redman; M. Chen is a Medicine article available to read on EtoBox.

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## Background: The most frequent cause of episodic heartburn is food and beverage ingestion. Nizatidine, an H~2~‐receptor antagonist, is currently approved for non‐prescription use in the prevention and relief of heartburn at a dose of 75 mg up to twice a day. ## Methods: Two identical studies were carried out to evaluate the efficacy of nizatidine, 75 mg, compared with placebo in treating heartburn in an ‘at‐home’ setting. The studies were multicentre, multiple‐dose, placebo‐controlled, randomized, parallel group design. A total of 994 subjects were randomized to treatment. Adequate relief of heartburn was assessed at 15, 30 and 45 min and 1, 2 and 3 h following a treatment dose. A subject’s responses with respect to time to relief and attainment of adequate relief were combined into a derived response profile, the sustained adequate relief score. Adverse experiences were noted throughout the study period. ## Results: The individual and combined study results showed that nizatidine, 75 mg, relieved heartburn faster and/or more consistently than placebo. The mean sustained adequate relief score, calculated over a subject’s first four episodes, was 2.43 in the nizatidine‐treated gro

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Author

K. Paul; C. M. Redman; M. Chen

Publisher

John Wiley and Sons; Blackwell Publishing; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0269-2813)

Published

2001

Language

EN

Field

Medicine (Health Sciences)