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Prognostic Value of Heparanase Expression and Cellular Localization in Oral Cancer by Yoav Leiser; Imad Abu‐El‐Naaj; Edmond Sabo; Sharon Akrish; Neta Ilan; Ofer Ben‐Izhak; Micha Peled; Israel Vlodavsky is a Medicine article available to read on EtoBox.

What is Prognostic Value of Heparanase Expression and Cellular Localization in Oral Cancer about?

## Abstract ## Background Metastases formation depends on the ability of tumor cells to invade basement membranes in a process involving enzymes capable of degrading extracellular matrix components. ## Methods We examined the expression of heparanase in oral carcinomas and correlated its staining extent, intensity, and cellular localization with patients' outcome. ## Results Quantitative real‐time polymerase chain reaction (PCR) revealed over 4‐fold increase in heparanase levels in oral carcinomas compared to adjacent normal tissue. Normal oral epithelium was found negative for heparanase, while all oral carcinomas stained positively for heparanase. Heparanase staining was associated with Ki67 staining, a measure of cell proliferation. Notably, whereas cytoplasmic localization of heparanase was associated with high‐grade carcinomas, nuclear localization of the enzyme was found primarily in low‐grade, well‐differentiated tumors, and in all oral verrucous carcinomas. ## Conclusion Expression level and cellular localization of heparanase could serve as an important diagnostic marker in patients with oral cancer. © 2010 Wiley Periodicals, Inc. Head Neck, 2011

Who reads Prognostic Value of Heparanase Expression and Cellular Localization in Oral Cancer?

Author

Yoav Leiser; Imad Abu‐El‐Naaj; Edmond Sabo; Sharon Akrish; Neta Ilan; Ofer Ben‐Izhak; Micha Peled; Israel Vlodavsky

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 1043-3074)

Published

2010

Language

EN

Field

Medicine (Health Sciences)