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## Background: Recent evidence suggests that the immunosuppressive drug cyclosporin may be of benefit in treating patients with severe colitis who are steroid resistant. Although cyclosporin appears to be effective in reducing colectomy rates in the short term, few data are available on the long‐term follow‐up of such patients. ## Aim: To investigate the short‐ and long‐term outcome of patients with severe steroid‐resistant ulcerative colitis treated with cyclosporin who were otherwise being considered for colectomy. ## Methods: Twenty‐two patients with severe steroid‐resistant exacerbations of ulcerative colitis who were being considered for colectomy were treated with cyclosporin (4 mg/kg i.v.) daily for 7 days followed by oral treatment (6 mg/kg/day) if colectomy was avoided. ## Results: Twenty of 22 patients (91%) avoided colectomy during their initial hospital admission. With a mean follow‐up period of 39 months (range 31–59), eight of these patients have subsequently relapsed and required colectomy and 12 patients have avoided colectomy (53%). Of the 12 patients avoiding colectomy, seven have successfully been weaned on to azathioprine while five are maintained on an aminosal

Author

Stack; Long; Hawkey

Publisher

John Wiley and Sons; Blackwell Publishing; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0269-2813)

Published

1998

Language

EN