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Isoniazid Tuberculosis Preventive Therapy in HIV-Infected Adults Accessing Antiretroviral Therapy: A Botswana Experience, 2004-2006 by Mosimaneotsile, Barudi; Mathoma, Anikie; Chengeta, Bafanana; Nyirenda, Samba; Agizew, Tefera B; Tedla, Zegabriel; Motsamai, Oaitse I; Kilmarx, Peter H; Wells, Charles D; Samandari, Taraz is a scholarly article available to read on EtoBox.

What is Isoniazid Tuberculosis Preventive Therapy in HIV-Infected Adults Accessing Antiretroviral Therapy: A Botswana Experience, 2004-2006 about?

Objectives: To describe reasons for exclusion from isoniazid tuberculosis preventive therapy (IPT) and outcomes of persons living with HIV (PLWH) during 6 months of IPT. ## Methods: In a clinical trial conducted in government clinics, first screening (screen 1) used National IPT Program guidelines and a second screening (screen 2) was trial specific. Adherence was defined as attending 6 monthly visits. Results: Between 2004 and 2006, at 4018 screening visits, 2934 (73%) PLWH met screen 1 criteria; 1995 (68%) met screen 2 criteria and were enrolled. Major reasons for exclusion were illness (66%) at screen 1 and abnormal chest radiographs (36%) at screen 2. Tuberculin skin tests were $5 mm in 24% of those enrolled and 31% had CD4 lymphocyte counts ,200 cells/mm 3 . During the 6 months, 8 (0.40%) developed tuberculosis disease, 28 (1.4%) had severe adverse events (19/28 were hepatitis including one death probably isoniazid-associated), 20 others died, and 22% initiated antiretroviral therapy (ART). Although adherence was 86%, being on ART improved adherence: relative risk 1.41 (95% confidence limits 1.04-1.91). In multivariate analysis, ART was associated with a 4.38 greater odds of a

Author

Mosimaneotsile, Barudi; Mathoma, Anikie; Chengeta, Bafanana; Nyirenda, Samba; Agizew, Tefera B; Tedla, Zegabriel; Motsamai, Oaitse I; Kilmarx, Peter H; Wells, Charles D; Samandari, Taraz

Publisher

Lippincott Williams and Wilkins; Lippincott Williams & Wilkins; Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins; Lippincott Williams & Wilkins Ltd.; Ovid Technologies (Wolters Kluwer Health) (ISSN 1077-9450)

Published

2010

Language

EN