Can I read A Logic‐Based Diagnostic and Therapeutic Hydrogel with Multistimuli Responsiveness to Orchestrate Diabetic Bone Regeneration on EtoBox?

A Logic‐Based Diagnostic and Therapeutic Hydrogel with Multistimuli Responsiveness to Orchestrate Diabetic Bone Regeneration by Dize Li; Kaiwen Chen; Han Tang; Shanshan Hu; Liangjing Xin; Xuan Jing; Qingqing He; Si Wang; Jinlin Song; Li Mei; Richard D. Cannon; Ping Ji; Huanan Wang; Tao Chen is a scholarly article available to read on EtoBox.

What is A Logic‐Based Diagnostic and Therapeutic Hydrogel with Multistimuli Responsiveness to Orchestrate Diabetic Bone Regeneration about?

## Abstract The regeneration of diabetic bone defects remains challenging as the innate healing process is impaired by glucose fluctuation, reactive oxygen species (ROS), and overexpression of proteinases (such as matrix metalloproteinases, MMPs). A “diagnostic” and therapeutic dual‐logic‐based hydrogel for diabetic bone regeneration is therefore developed through the design of a double‐network hydrogel consisting of phenylboronic‐acid‐crosslinked poly(vinyl alcohol) and gelatin colloids. It exhibits a “diagnostic” logic to interpret pathological cues (glucose fluctuation, ROS, MMPs) and determines when to release drug in a diabetic microenvironment and a therapeutic logic to program different cargo release to match immune‐osteo cascade for better tissue regeneration. The hydrogel is also shown to be mechanically adaptable to the local complexity at the bone defect. Furthermore, the underlying therapeutic mechanism is elucidated, whereby the logic‐based cargo release enables the regulation of macrophage polarization by remodeling the mitochondria‐related antioxidative system, resulting in enhanced osteogenesis in diabetic bone defects. This study provides critical insight into the

Author

Dize Li; Kaiwen Chen; Han Tang; Shanshan Hu; Liangjing Xin; Xuan Jing; Qingqing He; Si Wang; Jinlin Song; Li Mei; Richard D. Cannon; Ping Ji; Huanan Wang; Tao Chen

Publisher

Wiley

Published

2022

Language

EN