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Effect of the Immune Responses Induced by Implants in a Integrated Three‐dimensional Micro‐nano Topography on Osseointegration by Yun Yang; Ting Zhang; Mengyang Jiang; Xiaojie Yin; Xiayan Luo; Huiqiang Sun is a Engineering article available to read on EtoBox.
What is Effect of the Immune Responses Induced by Implants in a Integrated Three‐dimensional Micro‐nano Topography on Osseointegration about?
In order to explore the abilities of an integrated three-dimensional micro-nano topography in immunomodulation and promoting bone formation, present study focuses on the titanium sheets used in the micro-nano topography by treating them with the sandblasted, large-grit and acid-etched (SLA)and alkaline thermal reaction. Further, we characterized and obtained the surface morphology, roughness, and hydrophilicity of the titanium sheets. Moreover, we detected their in vitro cytocompatibility and cell proliferation as well. In addition, investigation was carried out for the immunomodulatory ability of the titanium sheets in a micro-nano topography by observing the expression of M1 (classical activated macrophage) and M2 (alternatively activated macrophage) type marker factors, inflammatory factors, and morphological changes of RAW264.7 cells cultured on the titanium sheets in different topographies. Through cell migration experiments and coculture, we observed the effects of different titanium sheet immune environments on osteoblast migration, extracellular matrix mineralization, and osteoblast gene expression. These results showed that the micro-nano topography constructed through SLA
Who reads Effect of the Immune Responses Induced by Implants in a Integrated Three‐dimensional Micro‐nano Topography on Osseointegration?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Yun Yang; Ting Zhang; Mengyang Jiang; Xiaojie Yin; Xiayan Luo; Huiqiang Sun
- Publisher
- Wiley
- Published
- 2020
- Language
- EN
- Field
- Engineering (Physical Sciences)