Can I read The relationship between the expression of Ki-67 and the prognosis of osteosarcoma on EtoBox?

The relationship between the expression of Ki-67 and the prognosis of osteosarcoma by Ming Zeng; Jian Zhou; Lifang Wen; Yanshan Zhu; Yingquan Luo; Wanchun Wang is a Medicine article available to read on EtoBox.

What is The relationship between the expression of Ki-67 and the prognosis of osteosarcoma about?

## Abstract ## Background A number of studies have linked positive Ki-67 expression with the prognosis of osteosarcoma (OS) patients. However, the results have been conflicting. To address this controversy, we conducted an analysis using a meta-analysis and a TCGA dataset to estimate the value of Ki-67 expression in the prognosis of OS. ## Methods A comprehensive search for relevant papers was conducted using NCBI PubMed, Embase, Springer, ISI Web of Knowledge, the Cochrane Library, and CNKI regardless of the publication year. The associations between Ki-67 expression and the clinical features and main prognostic outcomes of OS were measured. The TCGA dataset was also analyzed. The pooled odds ratio (OR) and its 95% confidential intervals (CIs) were utilized for statistical analysis. ## Results Overall, a total of 12 studies with 500 cases were included, and the results indicated that the expression of Ki-67 was significantly associated with Enneking stage (OR = 6.88, 95% CI: 2.92–16.22, p < 0.05), distant metastasis (OR = 3.04, 95% CI: 1.51–6.12, p < 0.05) and overall survival (OR = 8.82, 95% CI: 4.68–16.65, p < 0.05) in OS patients. Additionally, we observed no significant hetero

Who reads The relationship between the expression of Ki-67 and the prognosis of osteosarcoma?

Author

Ming Zeng; Jian Zhou; Lifang Wen; Yanshan Zhu; Yingquan Luo; Wanchun Wang

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Medicine (Health Sciences)