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Hydrogen Sulfide: A Potential Therapeutic Target in the Development of Diabetic Retinopathy by Mohammad, Ghulam ;Radhakrishnan, Rakesh ;Kowluru, Renu A. is a Medicine article available to read on EtoBox.

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## Purpose: Hyperglycemia damages the retinal mitochondria, and the mitochondrial damage plays a central role in the development of diabetic retinopathy. patients with diabetes also have higher homocysteine levels, and abnormalities in homocysteine metabolism result in decreased levels of hydrogen sulfide (h2s), an endogenous gasotransmitter signaling molecule with antioxidant properties. this study aimed to investigate the role of h2s in the development of diabetic retinopathy. ## Methods: Streptozotocin-induced diabetic mice were administered a slow releasing h2s donor gyy4137 for 6 months. the retina was used to measure h2s levels, and their retinal vasculature was analyzed for the histopathology characteristic of diabetic retinopathy and oxidative stress, mitochondrial damaging matrix metalloproteinase-9 (mmp-9), and mitochondrial integrity. these parameters were also measured in the isolated retinal endothelial cells incubated in high glucose medium containing gyy4137. ## Results: Administration of gyy4137 to diabetic mice ameliorated decrease in h2s and prevented the development of histopathology, characteristic of diabetic retinopathy. diabetes-induced increase in oxidative

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Author

Mohammad, Ghulam ;Radhakrishnan, Rakesh ;Kowluru, Renu A.

Publisher

Association for Research in Vision and Ophthalmology (ARVO)

Published

2020

Language

EN

Field

Medicine (Health Sciences)