Can I read Randomized Controlled Trial of Live Lactobacillus Acidophilus Plus Bifidobacterium Bifidum in Prophylaxis of Diarrhea During Radiotherapy in Cervical Cancer Patients on EtoBox?

Randomized Controlled Trial of Live Lactobacillus Acidophilus Plus Bifidobacterium Bifidum in Prophylaxis of Diarrhea During Radiotherapy in Cervical Cancer Patients by Imjai Chitapanarux; Taned Chitapanarux; Patrinee Traisathit; Sudkaneung Kudumpee; Ekkasit Tharavichitkul; Vicharn Lorvidhaya is a Medicine article available to read on EtoBox.

What is Randomized Controlled Trial of Live Lactobacillus Acidophilus Plus Bifidobacterium Bifidum in Prophylaxis of Diarrhea During Radiotherapy in Cervical Cancer Patients about?

## Background: Radiation-induced diarrhea is frequently observed during pelvic radiotherapy. this study was performed to determine the ability of a probiotic containing live lactobacillus acidophilus plus bifidobacterium bifidum to reduce the incidence of radiation-induced diarrhea in locally advanced cervical cancer patients. ## Methods: Patients who were undergoing pelvic radiotherapy concurrent with weekly cisplatin were randomly assigned to a study drug or placebo, in a double-blind study. diarrhea was graded weekly according the common toxicity criteria (ctc) system. stool consistency and white and red blood cell count in stool were also assessed. the primary endpoint was to reduce the incidence of diarrhea, defined by a ctc grade 2 or more, and the need for anti-diarrheal medication. ## Results: A total of 63 patients were enrolled. grade 2 -3 diarrhea was observed in 45% of the placebo group (n = 31) and 9% of the study drug group (n = 32) (p = 0.002). anti-diarrheal medication use was significantly reduced in the placebo group (p = 0.03). the patients in the study drug group had a significantly improved stool consistency (p < 0.001). ## Conclusions: Live lactobacillus acido

Who reads Randomized Controlled Trial of Live Lactobacillus Acidophilus Plus Bifidobacterium Bifidum in Prophylaxis of Diarrhea During Radiotherapy in Cervical Cancer Patients?

Author

Imjai Chitapanarux; Taned Chitapanarux; Patrinee Traisathit; Sudkaneung Kudumpee; Ekkasit Tharavichitkul; Vicharn Lorvidhaya

Publisher

BioMed Central; Springer (Biomed Central Ltd.); [London]: BioMed Central, 2006-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1748-717X)

Published

2010

Language

EN

Field

Medicine (Health Sciences)