Can I read A Pilot Study Evaluating the Efficacy and Safety of Retinaldehyde‐loaded Niosomes Against Mild‐to‐moderate Acne on EtoBox?

A Pilot Study Evaluating the Efficacy and Safety of Retinaldehyde‐loaded Niosomes Against Mild‐to‐moderate Acne by Jihee Kim; Jemin Kim; Young In Lee; Jangmi Suk; Dongwon Lee; Ju Hee Lee is a Medicine article available to read on EtoBox.

What is A Pilot Study Evaluating the Efficacy and Safety of Retinaldehyde‐loaded Niosomes Against Mild‐to‐moderate Acne about?

## Abstract ## Background Retinoids are the mainstay of topical therapy for acne. To improve the efficacy and minimize the side effects of retinoids, various novel drug delivery mechanisms, including nanoparticles, have been developed. ## Aim To evaluate the efficacy and safety of a retinaldehyde‐loaded niosome (RA‐N) nanoemulsion against sebum secretion and keratinization on mild‐to‐moderate acne. ## Patients/methods Twenty‐three participants exhibiting mild‐to‐moderate acne with both closed and open comedones were included. They applied a 0.05% RA‐N nanoemulsion daily for 4 weeks, did not to use any other emollient or topical pharmaceutical, and were asked to report any symptoms and treatment satisfaction. ## Results The participants demonstrated significantly fewer closed and open comedones after 2 and 4 weeks of treatment than at baseline (\*p < 0.05). The mean sebum secretion, measured using Sebumeter®, was 327.95 ± 90.20 μg cm^−2^ at baseline and reduced to 282.60 ± 99.70 and 250.65 ± 97.6 μg cm^−2^, respectively, after 2 and 4 weeks of treatment (\*p < 0.05). The mean desquamation index, determined using Visioscan®, was 10.99 ± 1.69 at baseline and decreased to 9.81 ± 1.10 a

Who reads A Pilot Study Evaluating the Efficacy and Safety of Retinaldehyde‐loaded Niosomes Against Mild‐to‐moderate Acne?

Author

Jihee Kim; Jemin Kim; Young In Lee; Jangmi Suk; Dongwon Lee; Ju Hee Lee

Publisher

Wiley

Published

2021

Language

EN

Field

Medicine (Health Sciences)