Opening book details…
Can I read Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRγ on EtoBox?
Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRγ by Esther Y.H. Chao; Jon L. Collins; Stéphanie Gaillard; Aaron B. Miller; Liping Wang; Lisa A. Orband-Miller; Robert T. Nolte; Donald P. McDonnell; Timothy M. Willson; William J. Zuercher is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRγ about?
The design and synthesis of 4-hydroxytamoxifen (4-OHT) derivatives are described. The binding affinities of these compounds toward the orphan estrogen-related receptor gamma and the classical estrogen receptor alpha demonstrate that analogs bearing hydroxyalkyl groups display improved binding selectivity profiles compared with that of 4-OHT. An X-ray crystal structure of one of the designed compounds bound to ERRgamma LBD confirms the molecular basis of the selectivity.
Who reads Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRγ?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Esther Y.H. Chao; Jon L. Collins; Stéphanie Gaillard; Aaron B. Miller; Liping Wang; Lisa A. Orband-Miller; Robert T. Nolte; Donald P. McDonnell; Timothy M. Willson; William J. Zuercher
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2006
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)